Iran has struck multiple locations in northern Israel in its retaliatory attacks, causing significant material damage.

At least five people were injured, according to Israeli public broadcaster KAN.

At least one killed, 14 others injured in Iran's retaliatory attacks in Israel in Tamra, Lower Galilee, Israeli media said.

Israel's firefighting service said residential buildings were hit and a fire started in the country's coastal and northern districts.

"Several incidents have been reported to the Israel Fire and Rescue Services command centres in the Coastal and Northern Districts, with hits on residential buildings and a fire in an open area", Israel Fire and Rescue Services spokesman Tal Volbovitz said in a statement.

Tensions between Israel and Iran are escalating dramatically late Saturday as both countries reportedly exchange direct military strikes.

According to multiple media reports, the Israeli military launched air strikes on military targets in Tehran, while Iranian missiles targeted sites inside Israel.

A Reuters witness reported seeing several missiles streaking over Jerusalem.

Sirens were activated across northern Israel, including in Haifa, Krayot and the Galilee region, as authorities warned of incoming threats.

The Israeli army confirmed it had detected missile launches from Iran and said it was responding by striking targets in Tehran.

Iranian state television said air defences were activated to respond to a drone attack at the strategic port of Bandar Abbas on the second day of Israel's strikes on the country.

“The air defence of Bandar Abbas was activated to combat micro-drones,” state TV reported without elaborating.

Citing an air defence commander, it also said that “over the past hour, 10 hostile Israeli aircraft were shot down in different areas” of the country.

Iran’s air defences shot down three Israeli drones over Qom province, the Crisis Management Centre in Qom said, amid escalating hostilities between the two countries.

In a statement, the centre confirmed the unmanned aerial vehicles were intercepted in the skies above Qom, home to the Fordo nuclear facility, which Israel has claimed to be among its targets during the latest round of air strikes.

The Iranian Navy intercepted a British destroyer in the northern Indian Ocean meant to help guide Israeli missiles toward Iranian territory, state news agency IRNA reported.

According to a statement from the public relations office of the First Naval Zone, the destroyer was detected by Iranian intelligence systems Friday night and warned by combat drones before it could advance towards the Gulf.

The vessel is said to have been forced to change course after being tracked in the Sea of Oman.

Amid intensifying Israel-Iran tension, a senior White House official said that a peaceful resolution remains within reach if Tehran is willing to abandon its nuclear weapons programme.

“Whatever happens today cannot be prevented,” the official told Anadolu.

“But we have the ability to negotiate a successful peaceful resolution to this conflict if Iran is willing. The fastest way for Iran to accomplish peace is to give up its nuclear weapons programme,” the official added.

Azerbaijan reassured neighbouring Iran that it would not allow its territory to be used for attacks against Tehran, following unprecedented Israeli strikes on Iranian targets.

“Azerbaijan will never allow its territory to be used for attacks on third countries, including friendly Iran,” Azerbaijan’s Foreign Minister Jeyhun Bayramov told his Iranian counterpart, Abbas Araghchi.

France’s President Emmanuel Macron urged his Iranian counterpart Masoud Pezeshkian to “quickly” resume negotiations over his country’s nuclear programme, as a conflict between Tehran and Israel escalated.

Fresh US-Iranian talks on Tehran’s nuclear programme that had been scheduled for Sunday were cancelled after Israel launched a massive wave of strikes on Iran, targeting nuclear facilities and killing top army commanders and atomic scientists.

Macron said in a message on X that he “invited President Pezeshkian to return swiftly to the negotiating table to reach an agreement — the only viable path to de-escalation”.