Russia downed 77 Ukrainian drones overnight, its defence ministry said Thursday, two days after Kiev carried out its largest direct strike on Moscow during the three-year war.

Thirty drones were intercepted and destroyed over the western Bryansk region bordering Ukraine while 25 more were downed over Kaluga, the ministry said in a statement.

More drones were intercepted over the regions of Kursk, Voronezh, Rostov and Belgorod, it added.

The latest barrage comes after Russia downed more than 90 drones in the capital region on Tuesday.

Mayor Sergei Sobyanin called it the "most massive enemy drone attack on Moscow". Russia said three people died and several more were injured in Tuesday's attack, which saw it intercept 337 Ukrainian drones across the country.

Multiple Ukrainian cities were also under attack Thursday morning, with a 42-year-old woman killed in Kherson, according to regional military administration head Roman Mrochko.

Authorities in Kiev and Dnipropetrovsk also reported coming under attack early Thursday.